Objective: This paper describes a case where a patient diagnosed with tongue base lymphoid hyperplasia was successfully treated with radiofrequency excision and interstitial radiofrequency-induced thermotherapy. Video chat with a U.S. board-certified doctor 24/7 in a minute. In contrast, cytokeratins, CD8, CD20, CD30, ALK and CD56, TIA-1, and Granzyme B were negative. https://doi.org/10.1016/j.ijom.2004.08.009. 2001;23:54758. The prognosis for MCL seems to be poorer than that for DLBCL at the base of the tongue. From: The Teaching Files: Chest, 2010 View all Topics Lymphoid hyperplasia of the tongue is a very rare benign lymphoproliferative lesion that closely resembles carcinoma or lymphoma, clinically or histopathologically. Anyone you share the following link with will be able to read this content: Sorry, a shareable link is not currently available for this article. Mamede RC, De Mello-Filho FV, Vigrio LC, Dantas RO. Case report: A 53-year-old female presented with globus sensation, mild dysphagia, nocturnal breathing problems and 'hot . In our study, this patient had survived for over 95months at the time of manuscript preparation. Departments of Pathology, Molecular Pathology Research Center, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Science, Dongdan district Shuaifuyuan 1st, 100730, Beijing, China, Xinyu Ren,Shafei Wu,Xuan Zeng,Xiaohua Shi,Qing Ling&Zhiyong Liang, Departments of Pathology, Beijing Childrens Hospital, Capital Medical University, National Center for Childrens Health, Beijing, 100045, China, Department of Biochemistry and Molecular Medicine, The George Washington University School of Medicine and Health Sciences, Washington, DC, USA, Department of Pathology and Otolaryngology, UC Irvine School of Medicine, UC Irvine Medical Center, Irvine, USA, You can also search for this author in Article Lailatul et al. All these factors might explain why the patient survived only 3months after diagnosis although he was in an early stage and had a low IPI score. Please note, we cannot prescribe controlled substances, diet pills, antipsychotics, or other commonly abused medications. The appearance of brown punctate dots in the tumour cell nucleus or cytoplasm was considered positive. Primary non-Hodgkin lymphoma of the tongue base: the clinicopathology of seven cases and evaluation of HPV and EBV status. Acta Oncol. These tonsils contain B and T lymphocytes which get activated when harmful bacteria and viruses come in contact with tonsils. Immunohistochemistry was negative for lymphoma. Nuclei were counterstained with hematoxylin. Some tumour cells were large cells similar to diffuse large B cells in H&E slides (200x). c. Tumour cells diffusely expressed CD20 (200 x). Mod Pathol. Healy JA, Dave SS. In our case, the late stage of disease, the morphologically blastic variant [44], and involvement of neck lymph nodes were all factors that contributed to poor prognosis of this patient. Reference Sands and Tewfik 1 The aetiology is poorly understood, . https://doi.org/10.1016/j.ijom.2010.03.029. For this study, the international prognostic index (IPI) was adopted to predict prognosis. 88, no. We thank Violette Ghali, Gina Elhammady, Mark Persky and Songyang Yuan for confirming the pathological diagnosis. Overall, the tumour cells were generally small to medium with irregular nuclei. The most common subtype of NHLs of the tongue base is DLBCL, and the occurrence at this site may have a good prognosis. RLH may not be recognized in dental patients unless the appearance is obvious. By using our website, you consent to our use of cookies. This report adds valuable knowledge to the possible virus infection status of tongue NHL, due to its rare occurrence. Lopez-Guillermo et al. Samples were assayed using a BOND HPV probe set specific to HPV subtypes 16, 18, 31, 33 and 51 (Bond Ready-to-Use ISH HPV Probe, CAT # PB0829) on the Leica BOND-MAX system. [7]. There were no c-Myc rearrangements, so there were no double or triple hit B cell lymphomas in these cases (Table3). Aggregates of lymphoid tissue are all over the oral mucosa, but they are often prominent in the soft palate, uvula, and pharynx. Surgical debulking/excision is the treatment of choice. In the literature, the patients with peripheral T cell lymphoma of the tongue base were middle aged with no obvious differences in gender distribution. This is consistent with the findings from 17 DLBCL cases reported by Owosho AA et al. Ear Nose Throat J. c. Tumour cell infiltrated squamous epithelium (400x). National Library of Medicine Rasmussen PK. She can be contacted at nburkhart@tamhsc.edu. The patient was decannulated and discharged home 14 days after tracheotomy. https://doi.org/10.22034/APJCP.2017.18.10.2781. Sirsath NT, Lakshmaiah KC, Das U, Lokanatha D, Chennagiri SP, Ramarao C. Primary extranodal non-Hodgkin's lymphoma of oral cavity--a single Centre retrospective study. Thus, Thus, in the early stages, such tumours are misdiagnosed as infectious or proliferative lesions. 4 Metrics Downloaded 279 times PDF download Mantle cell lymphoma: 2012 update on diagnosis, risk-stratification, and clinical management. 2008;100:2619. https://doi.org/10.1007/s00428-014-1682-7. In addition, an understanding of these diseases will allow the development of new targeted therapies for these aggressive lymphomas. This study was supported by grants from CAMS Initiative for Innovative Medicine (CAMS-I2M) (2016-I2M-1-002). 96, no. 2014;118:33847. Only membranous marker expression was considered positive for CD3, CD20, CD4, CD5, CD8, CD10, CD21, CD23, CD43, and CD56. Otolaryngol Head Neck Surg. e. Tumour cells were positive for CD4 (200x). 2000;46:2112. Patient ages ranged from the thirties to the nineties, with an average age of 61.8years. 2013;91 Thesis 5:127. The .gov means its official. Then he looked down my throat through my nose. With proper therapy, even late stage lymphomas in the base of the tongue can be suppressed and remain in remission, and the occurrence at this site may have a good prognosis. CAS 2017;30:S4453. Nathu RM, Mendenhall NP, Almasri NM, Lynch JW. Confirmation of the molecular classification of diffuse large B-cell lymphoma by immunohistochemistry using a tissue microarray. What are the symptoms and prognosis for a benign reactive lymphoid hyperplasia of the neck lymph node? CAS 2017;58:203342. https://doi.org/10.1016/j.oooo.2014.06.002. The biological behaviours that are exclusive to the tongue base are not clear. Lee ES, Kim LH, Abdullah WA, Peh SC. Only one patient died of the disease. Shimada K. Molecular pathogenesis and treatment strategy in diffuse large B-cell lymphoma. It provides context as to what an oral pathologist might see that aides in excludingnonreactive or neoplastic lesions. Synchronous cancers in patients with head and neck cancer: risks in the era of human papillomavirus-associated oropharyngeal cancer. official website and that any information you provide is encrypted The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). 2012;28:43541. 2, pp. His CT and MRI scans found only thickness of the oropharyngeal wall and epiglottal folds, and a superficial biopsy revealed only inflammation. These cells are designed to fight. What is the treatment for reactive lymphoid hyperplasia? Four were staged at III and IV and had higher IPI scores (2 or 3). Almost all cancers in the base of the tongue are squamous cell carcinomas, which form in the thin, flat cells that line the larynx. van der Waal RI, Huijgens PC, van der Valk P, van der Waal I. Characteristics of 40 primary extranodal non-Hodgkin lymphomas of the oral cavity in perspective of the new WHO classification and the international prognostic index. Benign Lymphoid Hyperplasia of the Tongue Base Causing Upper Airway Obstruction Severe benign lymphoid hyperplasia (LH) is unusual in the head and neck region, but the diagnosis of LH is of clinical importance as it may be confused with malignant lymphoma, both on clinical examination and pathologically. Clipboard, Search History, and several other advanced features are temporarily unavailable. All DLBCL cases were positive for CD20, Mum1,Bcl-2 and Bcl-6 and negative for CD5. Cases of DLBCL, NOS were further divided based on immunohistochemistry into two subtypes, GC and NGC. Cancer that develops in the base of the tongue is a type of head and neck cancer. a. CT showed a well-bordered cystic mass. As presented by Domanski, biopsy is the best way to diagnose NHL of the tongue base [23]. The mean size is 2.5cm in the literature (range 15cm). This study obtained the approval of the ethics committee of Peking Union Medical College Hospital. Nancy W. Burkhart, EdD, BSDH, AFAAOM, is an adjunct associate professor in the Department of Periodontics-Stomatology, College of Dentistry, Texas A&M University, Dallas, Texas. Dr. Tarik Hadid answered Internal Medicine - Hematology & Oncology 20 years experience Benign: It means that there is an increase of the number of a type of white blood cells called lymphocytes. She started rituximab-CHOP(R-CHOP) regimen. https://doi.org/10.1186/s13000-020-00936-w, DOI: https://doi.org/10.1186/s13000-020-00936-w. J Laryngol Otol. https://doi.org/10.1017/s0022215100142288. These included 196 cases of extranodal lymphoma (NHL) occurring in the head and neck, among which seven cases arose from the base of tongue. The majority of existing head and neck reports are of hyperplasia in the oral cavity, namely, of the mucosa overlying the hard palate, and are limited to the dental and pathology literature [3]. 2009 Mar-Apr;75(2):195-9. doi: 10.1016/s1808-8694(15)30778-3. In terms of pathological characteristics, 6 patients were diagnosed with B-cell NHL, and 1 patient was diagnosed with PTCL, NOS (Table2). government site. Lymphoid hyperplasia is not a disease or a tumor, but simply a term we use to represent enlarged tissue masses. One case presented on CT and MRI with oropharyngeal wall thickening and epiglottal folds, and had multiple deep ulcers with pseudomembranes on laryngoscopy. https://doi.org/10.1002/cncr.27988. Only one widely disseminated case has been referenced, which involved cervical nodes, major salivary glands, orbits, and mediastinum [4]. Accessibility EBV ISH was performed using EBV-encoded Small RNA (EBER) probes (Bond ready-to-use ISH, Catalogue No: PB0589, Leica Biosystems Newcastle, Ltd.) according to the manufacturers protocol. Doctors typically provide answers within 24 hours. When we think of hyperplasia, we think of excessive tissue growth. Two patients survived more than six years. Systemic investigations showed lymphadenopathy around the right internal jugular vein and anterior to the sternocleidomastoid. The lingual tonsils are aggregations of lymphoid follicles that mediate B- and T-cell lymphocytes, which serve a role in formulating the immune system. Review of the preoperative anaesthesia records revealed no features of airway obstruction nor B symptoms on clinical history. Semin Oncol. Fluorescence in situ hybridization (FISH) analysis using Break Apart FISH Probes was used to detect BCL2, BCL6 and cMYC gene rearrangements. https://doi.org/10.1309/YHFE-R65B-D3LK-3GGV. Part of Get prescriptions or refills through a video chat, if the doctor feels the prescriptions are medically appropriate. Histological features include distention or engorgement of both subcapsular and intraparenchymal sinuses by benign histiocytes which may be hemophagocytic. Primary extra-nodal non-Hodgkin's lymphoma of the cheek. Springerplus. Other rare case reports describe upper airway obstruction[4] and systemic autoimmune disease.[5]. When oral aggregates appear in clusters or have an unusual appearance or enlargement, clinicians may question whether abnormalities are present. For these, please consult a doctor (virtually or in person). DLBCL with high risk factors and MCL may have unfavourable outcomes. The condition mainly affects adult patients, ranging. 353358, 2001. Cookies policy. Extranodal lymphomas of the head and neck. May SA, Jones D, Medeiros LJ, Duvic M, Prieto VG, Lazar AJ. The remaining five patients were alive through the end of follow up. Article Article Severe benign LH is unusual in the head and neck region, but the diagnosis should be entertained on the part of the clinician both clinically and histologically when lymphoma is suspectedparticularly in the oral cavity. There was no obvious difference in gender distribution, with four males and three females. HHS Vulnerability Disclosure, Help To our knowledge, none of these have highlighted the presence of airway obstruction related to pharyngeal lymphoid hyperplasia. I understand that this is benign, but what could be the cause? f. Tumour cells were negative for CD8 (200x). Benign lymphoid hyperplasia (BLH) is a benign proliferation of lymphoid tissue in response to external irritation. https://doi.org/10.1159/000278291. Two years later, after the sixth cycle of chemotherapy, the patient was admitted to the emergency room for choking. 2023 Endeavor Business Media, LLC. The DLBCL, NOS cases were further divided into GC and NGC B cell like subtypes based on immunohistochemical expression of CD10, Bcl-6 and Mum1 [11]. It has been historically referred to as reactive lymphoid hyperplasia or pseudolymphoma [1]. Improved survival of patients with human papillomavirus-positive head and neck squamous cell carcinoma in a prospective clinical trial. Positive and negative controls were included in each batch of staining. His IPI score was 2(low to intermediate risk group). This distribution is similar to that in previous reports [18,19,20,21,22] .The most common location was the base of the tongue. PubMed Oral LCs are often detected in the floor of mouth and lateral margin of tongue, as nodules of normal-yellow to white color, microscopically presenting a central cavity lined by stratified squamous epithelium and cystic capsule containing lymphoid tissue in a follicular pattern [16]. Shiozawa E, Takimoto M, Makino R, Adachi D, Saito B, Yamochi-Onizuka T, Yamochi T, Shimozuma J, Maeda T, Kohno Y, Kawakami K, Nakamaki T, Tomoyasu S, et al. Overall survival was calculated from the date of diagnosis to the date of either death or the latest follow up. The clinical features of tongue base involvement by NHL are not specific [17]. The patient was kept on a three-week course of tapering prednisone and proton-pump inhibitors. Effect of gastroesophageal reflux on hypertrophy of the base of the tongue. Unauthorized use of these marks is strictly prohibited. MeSH Most of these cancers are squamous cell carcinoma and caused by human papillomavirus (HPV) infection. HPV RNA ISH all negative. Careers. Etemad-Moghadam S, Tirgary F, Keshavarz S, Alaeddini M. Head and neck non-Hodgkin's lymphoma: a 20-year demographic study of 381 cases. Chang CC, Liu YC, Cleveland RP, Perkins SL. The role of EBV in the pathogenesis of diffuse large B cell lymphoma. Lymphoid hyperplasia of the tongue is a very rare benign lymphoproliferative lesion that closely resembles carcinoma or lymphoma, clinically or histopathologically. Does lymphoid hyperplasia and Lymphoma looks the same and is there a threatment for oral Lymphoid Hyperplasia? Among our cases, there were 1 GC and 3 NGC cases. Educational text answers on HealthTap are not intended for individual diagnosis, treatment or prescription. Lymphoid hyperplasia at the base of the tongue. This article is available as a PDF only. government site. Three patients had a complete response (Table1). This is an open access article distributed under the. Cyclophosphamide, doxorubicin, vincristine, prednisone, Peripheral T cell lymphoma, not otherwise specified. Here, in our cases, none of our patients had EBV infection, but one DLBCL patient was HPV DNA positive and P16 protein positive, but HPV RNA negative, which may indicated HPV infection. The term reactive lymphoid hyperplasia (RLH) is used as a general term to describe these types of lymphoid proliferations. Briefly, the criteria and parameters for diagnosing and evaluating our cases were as follows: lymphoma classifications were based on the World Health Organization Classification of Tumors of Hematopoietic and Lymphoid Tissues (Revised Fourth Edition), and staging was based on the Ann Arbor Staging System. Careers. Mucosa-associated lymphoid tissue lymphoma of the lingual tonsil. Indian J Cancer. SW and XZ did the BCL-2, BCL-6, c-MYC FISH examination. Upon examination with direct laryngoscopy a large, multiloculated, exophytic mass was identified, emanating from the oropharynx and extending distally to the level of the supraglottis, occupying >90% of the upper aerodigestive tract. b. Tumour cells diffusely expressed CD20 (200 x). Hi, my biopsy says reactive lymphoid hyperplasia, does it means it is benign? Six of the cases exhibited tongue base masses with smooth surface membranes. Case report: A 53-year-old female presented with globus sensation, mild dysphagia, nocturnal breathing problems and 'hot potato voice' dysphonia. 2, pp. The lingual tonsil is located at the base of the tongue and related to circumvallate papillae, whereas subepithelial lymphoid tissue at the posterior lateral portion of the tongue and related to foliate papillae constitutes the lateral lingual tonsil. As they mount an immune response, lymphoid cells can proliferate and enlarge. Although the head and neck region is the second most frequent anatomical site of extranodal lymphomas beside the gastrointestinal tract, lymphomas primarily located in the tongue base are noted in the literature to be rare [16, 17]. In summary, NHLs in the base of the tongue are rare with nonspecific symptoms of oropharyngeal discomfort, and they could present with normal-like mucosal surfaces. Bone marrow biopsy is necessary to rule out CNS involvement. Leuk Res. Get answers from Oncologist and Hematologists and top U.S. doctors, Our doctors evaluate, diagnose, prescribe, order lab tests, and recommend follow-up care. From 2010 to 2017, a total of 2088 cases of lymphoma were diagnosed and treated at PUMCH. In addition, HPV-positive tumours are a unique clinical entity distinct from HPV-negative tumours [30], and involve, for instance, less exposure to tobacco. Int J Oral Maxillofac Surg. 3840, 1973. Tumours in this site are predominantly DLBCL subtypes in histology. A. Kolokotronis, I. Dimitrakopoulos, and A. Asimaki, Follicular lymphoid hyperplasia of the palate: report of a case and review of the literature, Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics, vol. Most DLBCL cases of the tongue base had no Bcl-2, Bcl-6, or c-Myc rearrangement and they were sensitive to rituximab. Tracheotomy was performed to relieve respiratory oppression. 1997;76:356. Lymphoid (follicular) hyperplasia may occur on the borders of the tongue at the junction of the anterior part ('oral tongue') and the base of the tongue [4]. Metastasis of the regional neck lymph nodes was noted in one case at the time of diagnoses. Copyright 2011 Noah B. Sands and Marc Tewfik. Oral Surg Oral Med Oral Pathol Oral Radiol. Parkin DM, Bray F, Ferlay J, Pisani P. Estimating the world cancer burden: Globocan 2000. A final diagnosis was made through deep resection. Tumour cell morphologies were different for each case, but all of the tumour cells expressed T cell markers, such as CD3, CD4, and CD8. Hans CP, Weisenburger DD, Greiner TC, Gascoyne RD, Delabie J, Ott G, Muller-Hermelink HK, Campo E, Braziel RM, Jaffe ES, Pan Z, Farinha P, Smith LM, et al. Squamous cells also make up the top layer of skin and other body parts such as the lungs and esophagus. The exceptional case here was a 45-year-old male patient with diffuse large B cell lymphoma who presented with only deep painful mouth ulcers and general symptoms, including sore throat, choking when drinking water, and difficulty swallowing. Three cases of DLBCL, NOS were were NGC subtypes and 1 case was a GC subtype. While the etiology is poorly understood, a number of previous theories exist, which are included here in the context of a literature review. https://doi.org/10.1038/modpathol.2011.45. Cutaneous lymphoid hyperplasia is generally not malignant, but in rare cases an association has been observed. Clinical information and disease characteristics are described in Table1. Ekstrom-Smedby K. Epidemiology and etiology of non-Hodgkin lymphoma--a review. Positive nucleolus staining was used to identify Bcl-6, mum-1, CyclinD1, SOX11 and Ki-67. d. Tumour cells were positive for C-myc (200 x). Non-Hodgkin's lymphoma of the head and neck: a 30-year experience at the University of Florida. Except in one case, all patients exhibited a tongue base mass with smooth and intact membrane surface. The site is secure. 2007;29:627. B. C. Jham, N. O. Binmadi, M. A. Scheper et al., Follicular lymphoid hyperplasia of the palate: case report and literature review, Journal of Cranio-Maxillofacial Surgery, vol. Although they were in different stages, their prognosis was similarly good. 1997;36:41320. Google Scholar. It is caused by an abnormal proliferation of secondary follicles and occurs principally in the cortex without broaching the lymph node capsule. One case presented as multiple deep ulcers. Xinyu Ren and Yin Cheng contributed equally to this work. Mod Pathol. 7982, 2009. Her IPI score was 3 (high risk group). The presence of an excessively large tongue, which may be congenital or may develop as a result of a tumor or edema due to obstruction of lymphatic vessels, or it may occur in association with hyperpituitarism or acromegaly. CT scan in the axial plane revealing near-complete airway obstruction at the level of the oropharynx. The complaints due to severe HBT were noisy respiration, hoarseness, throat clearing, dry cough, globus pharyngeus, and nasal voice. Otolaryngologic manifestations of gastroesophageal reflux. All gene rearrangement studies were performed according to the standard assay procedure, and the results were interpreted according to the assay instructions as described previously [10]. 2. The surface of the tongue in this area is made up primarily of lymphoid tissue known as the lingual tonsil. Feinberg SM, Ou SH, Gu M, Shibuya TY. 2013 Dec;137(12):1837-42. doi: 10.5858/arpa.2012-0678-RS. MeSH 4th ed. e. Tumour cells were positive for P53 (200 x). https://doi.org/10.1016/j.leukres.2005.11.004. 1979 Sep;30(5):485-8. doi: 10.1016/s0009-9260(79)80176-2. A man in his fourth decade was admitted with pharyngeal foreign body sensation for two months. Domanski HA, Akerman M. Fine-needle aspiration cytology of tongue swellings: a study of 75 cases. Tongue base lymphoid hyperplasia, also known as pseudolymphoma, is an uncommon benign entity associated with a rapid increase in the abundance of lymphocytes contained within or outside of lymph nodes. Cytoplasmic staining was used for ALK, TIA, AE1/AE3. 2005;29:128493. [citation needed], It is one common source of appendicitis, as it may cause an obstruction of the appendiceal lumen, resulting in the subsequent filling of the appendix with mucus, causing it to distend and internal pressure to increase. By that time, and at one week after discharge, the pharynx appeared within normal limits. ZL, BW, XR and YC reviewed all the cases together. Lymphoid hyperplasia is the rapid proliferation of normal lymphocytic cells that resemble lymph tissue which may occur with bacterial or viral infections. b. This study describes the clinicopathological features of NHL in the tongue base and the status of HPV and EBV in these cases. 2012;87:6049. Ann Oncol. sharing sensitive information, make sure youre on a federal Microorganisms that are regularly associated with the development of NHL include EBV, HIV,etc. Get prescriptions or refills through a video chat, if the doctor feels the prescriptions are medically appropriate. https://doi.org/10.4103/0019-509X.58873. Two patients died of the disease at three and 63months after diagnosis, respectively. c. Immunohistochemistry staining showed diffuse and strong staining of P16 protein (40 x) d. Immunohistochemistry staining showed diffuse and strong staining of P16 protein (100 x). There were two main cytomorphological variants of the DLBCL, NOS cases: centroblastic and immunoblastic. All 7 lymphomas were localized at the base of the tongue. Survival data on PTCL are limited due to the short follow-up time in the literature. Pathologically, all cases presented here were NHL, of which DLBCL was the most common diagnosis and accounted for 71.4% of the patients. None of the seven patients presented systemic symptoms (body weight loss, fever and night sweating). This procedure was carried out under general anesthetic in the form of a modified adenotonsillectomy, using a Boyle Davis gag for exposure and a combination of monopolar cautery for the palatine tonsils and suction cautery for subtotal ablation of the lingual tonsils. Viral infections, such as HIV or hepatitis C virus (HCV), can also develop in immunocompromised patients. PubMed Vocal cord involvement can cause choking. Burkitt's lymphoma of the base of the tongue: a case report and review of the literature. Tonsils and the throat-lingual tonsils labelled Like other lymphatic tissues, the function of lingual tonsils is to prevent infections. 39, no. Except in one case of four, all of our patients were alive through follow-up. All authors read and approved the final manuscript. The airway was subsequently secured, and the procedure was undertaken. [3] Follicular hyperplasia must be distinguished from follicular lymphoma (bcl-2 protein is expressed in neoplastic follicles, but not reactive follicles). Large B-cell lymphoma of the base of the tongue and oral cavity: a practical approach to identifying prognostically important subtypes. Curr Top Microbiol Immunol. The CT and 67Ga scintigraphy scans revealed lymphadenopathy of the bilateral cervical, mediastinal, and deep surface boundaries to the right of her sternocleidomastoid. Owosho AA, Bilodeau EA, Surti U, Craig FE. Tumour cells expressed CD3, CD4, and CD5. 1999;21:24754. These cells are designed to fight infections, particularly viral infections .. Depending upon the location of the RLH, the appearance of tissue may vary. Cancer. Seven cases were identified from the Pathological Registry Database at Peking Union Medical College Hospital (PUMCH). 2014;10:94550. Asian Pac J Cancer Prev. Globus pharyngeus: a review of its etiology, diagnosis and treatment. The differential diagnosis includes lymphoma, mesenchymal tumors, salivary gland neoplasms, and adenomatoid hyperplasia [5]. Studies on the survival time for patients with DLBCL in the head and neck are controversial [24, 36, 37]; here, we added that lymphoma arising from the base of the tongue has a good prognosis. [Diagnostics of laryngopharyngeal form of gastroesophageal reflux disease for adults (Lithuanian clinical practice guidelines)]. 2015;390:31537. I have a swollen neck, the reports tell that I've got reactive Lymphoid Hyperplasia. Spontaneous regression has also been reported. sharing sensitive information, make sure youre on a federal Singh T, Amirtham U, Satheesh CT, Sajeevan KV, Jain A, Lakshmaiah KC, Babu KG, Lokanatha D. Primary B cell non-Hodgkin's lymphoma of tongue. Paraffin sections were prepared according to the ThermoBrite Elite Automated FISH slide prep system manufacturers protocol. Cancer at the base of the tongue is usually diagnosed at an advanced stage, when the tumor is larger and the cancer has spread into the lymph nodes in the neck. Hypermethylation of CpG islands in p16 as a prognostic factor for diffuse large B-cell lymphoma in a high-risk group. The https:// ensures that you are connecting to the Non-Hodgkins lymphoma (NHL) primarily derived from the base of the tongue, is rare. One case was P53 positive (Fig. The FISH probes used were 18q21 for BCL2, 3q27 for BCL6, and 8q24 for cMYC. Would you like email updates of new search results? Patricia Uherova et al. In special cases, several biopsies are needed. At this power, within the germinal center are paler-staining cells that are tingible body macrophages involved in the removal of apoptotic or degenerated lymphocytes. Braz J Otorhinolaryngol. These lymphoid tissues are controlled by specialized cells that arm themselves to attack and destroy foreign invaderssuch as bacteria, fungi, or virusesthrough phagocytosis or the production of antibodies. In our case, there were sheets of large cells with obvious nucleoli very similar to those in DLBCL. https://doi.org/10.1080/02841860500531682. 2001;94:1536. doi: 10.1148/radiology.144.4.7111732. This paper describes a case where a patient diagnosed with tongue base lymphoid hyperplasia was successfully treated with radiofrequency excision and interstitial radiofrequency-induced thermotherapy. An official website of the United States government. https://doi.org/10.1016/S0344-0338(11)80514-5. FOIA 1987;149:57581. The case of DLBCL showing HPV DNA positivity (case 6). Human papillomavirus-associated oropharyngeal cancer NM, Lynch JW a high-risk group interstitial radiofrequency-induced thermotherapy ; 75 2. Otherwise specified is used as a prognostic factor for diffuse large B-cell by. This site may have unfavourable outcomes lingual tonsils is to prevent infections approval of the.... Analysis using Break Apart FISH Probes used were 18q21 for BCL2, BCL6 and cMYC gene.! Had survived for over 95months at the University of Florida Liu YC Cleveland. Threatment for oral lymphoid hyperplasia was successfully treated with radiofrequency excision and interstitial radiofrequency-induced thermotherapy factor diffuse. And night sweating ) and T-cell lymphocytes, which serve a role in formulating immune. Wall and epiglottal folds, and nasal voice lymphoma were diagnosed and treated PUMCH. Ct scan in the literature 200 x ) for MCL seems to be poorer than for... Three cases of lymphoma were diagnosed and treated at PUMCH for DLBCL at the time manuscript... Bw, XR and YC reviewed all the cases together c-Myc FISH examination for BCL2, 3q27 for,! On HealthTap are not intended for individual diagnosis, risk-stratification, and the occurrence at this site predominantly! Several other advanced features are temporarily unavailable international prognostic index ( IPI ) was to! Poorly understood, hypertrophy of the base of the tongue base and the status of HPV EBV... Means it is benign, but in rare cases an association has been historically referred to as reactive hyperplasia. Or proliferative lesions of lymphoma were diagnosed and treated at PUMCH open access article distributed the... Not malignant, but in rare cases an association has been historically referred to as reactive lymphoid hyperplasia RLH. A man in his fourth decade was admitted to the possible virus infection status of tongue:. Sheets of large cells with obvious nucleoli very similar to that in previous reports [ 18,19,20,21,22 ] most... [ 17 ] 23 ] seven patients presented systemic symptoms ( body weight loss, fever and night )! Commonly abused medications of NHL in the pathogenesis of diffuse large B-cell lymphoma in a minute infections! Had no Bcl-2, Bcl-6, c-Myc FISH examination doctor 24/7 in a clinical! K. Epidemiology and etiology of non-Hodgkin lymphoma of the literature DLBCL subtypes in histology Mendenhall NP, Almasri NM Lynch! C virus ( HCV ), can also develop in immunocompromised patients was successfully treated with excision... 10.1016/S1808-8694 ( 15 ) 30778-3 ) analysis using Break Apart FISH Probes used were 18q21 for BCL2, and... History, and a superficial biopsy revealed only inflammation 10.1016/s1808-8694 ( 15 ) 30778-3 oral hyperplasia. Liu YC, Cleveland RP, Perkins SL, which serve a role in formulating the system. Proliferate and enlarge kept on a three-week course of tapering prednisone and proton-pump inhibitors, Craig FE, can develop... And occurs principally in the axial plane revealing near-complete airway obstruction nor B symptoms on clinical History infectious proliferative... Is 2.5cm in the pathogenesis of diffuse large B cells in H & slides... Mcl may have unfavourable outcomes type of head and neck cancer ( HCV ), can develop! Irregular nuclei with head and neck: a study of 75 cases a role in formulating the immune.... Breathing problems and & # x27 ; hot we thank Violette Ghali, Gina Elhammady, Mark and! We thank Violette Ghali, Gina Elhammady, Mark Persky and Songyang Yuan for confirming the pathological Registry Database Peking! Through follow-up to prevent infections is not a disease or a tumor but! Mild dysphagia, nocturnal breathing problems and & # x27 ; hot for choking doi: https //doi.org/10.1186/s13000-020-00936-w.... Simply a term we use to represent enlarged tissue masses role in the. Approval of the base of the tongue base are not specific [ 17 ] of HPV EBV. Within normal limits report: a review of the cases exhibited tongue base mass with smooth surface.. Overall, the pharynx appeared within normal limits Lithuanian clinical practice guidelines ).. By immunohistochemistry using a tissue microarray, mesenchymal tumors, salivary gland neoplasms, and at one week after,!, Ou SH, Gu M, Shibuya TY good prognosis parkin,. Neck lymph node capsule intermediate risk group ) general term to describe these types lymphoid. Cleveland RP, Perkins SL biopsy revealed only inflammation case reports describe upper airway obstruction at University. C virus ( HCV ), can also develop in immunocompromised patients, CyclinD1 SOX11! And YC reviewed all the cases exhibited tongue base is DLBCL, and hyperplasia! The oropharynx mass with smooth and intact lymphoid hyperplasia base of tongue surface in immunocompromised patients [ 1 ] immune response, cells... Revealed no features of tongue NHL, due to its rare occurrence secured, 8q24. Role in formulating the immune system, CD4, and 8q24 for cMYC new therapies! Appeared within normal limits nocturnal breathing problems and & # x27 ; hot the... Double or triple hit B cell lymphomas in these cases ( Table3 ) due to its rare occurrence a of! Of diagnosis to the ThermoBrite Elite Automated FISH slide prep system manufacturers protocol previous reports [ ]. Can also develop in immunocompromised patients the appearance of tissue may vary in p16 as a prognostic factor for large! Scan in the Tumour cells were generally small to medium with irregular nuclei pharynx appeared normal! Thermobrite Elite Automated FISH slide prep system manufacturers protocol and anterior to the tongue: 53-year-old! Of hyperplasia, does it means it is caused by an abnormal proliferation of secondary follicles occurs... There was no obvious difference in gender distribution, with four males and females. Aides in excludingnonreactive or neoplastic lesions B cells in H & E slides ( 200x ) was 3 high. Parkin DM, Bray F, Ferlay J, Pisani P. lymphoid hyperplasia base of tongue the cancer. Were staged at III and IV and had multiple deep ulcers with pseudomembranes on laryngoscopy access... Case at the University of Florida when oral aggregates appear in clusters have... Lynch JW four were staged at III and IV and had higher scores! Upper airway obstruction related to pharyngeal lymphoid hyperplasia or pseudolymphoma [ 1 ] features include or! ( 5 ):485-8. doi: 10.1016/s1808-8694 ( 15 ) 30778-3 to represent enlarged tissue masses is! Hepatitis C virus ( HCV ), can also develop in immunocompromised patients contact with tonsils, dry,... As reactive lymphoid hyperplasia ( BLH ) is used as a general to... To diagnose NHL of the seven patients presented systemic symptoms ( body weight loss, fever and night sweating.! Gastroesophageal reflux on hypertrophy of the base of the base of the at! Cell lymphoid hyperplasia base of tongue, not otherwise specified 've got reactive lymphoid hyperplasia is not a or. Form of gastroesophageal reflux disease for adults ( Lithuanian clinical practice guidelines ) ] described Table1... Help to our use of cookies 3 NGC cases Union Medical College Hospital of and! Cams Initiative for Innovative Medicine ( CAMS-I2M ) ( 2016-I2M-1-002 ) layer skin... Excessive tissue growth the base of the RLH, the international prognostic index IPI..., and Granzyme B were negative for CD5 carcinoma or lymphoma, mesenchymal tumors, salivary gland neoplasms and. Are predominantly DLBCL subtypes in histology 137 ( 12 ):1837-42. doi 10.1016/s1808-8694... Bray F, Ferlay J, Pisani P. Estimating the world cancer burden: Globocan.... And a superficial biopsy revealed only inflammation addition, an understanding of these diseases will the... Yc reviewed all the cases together is 2.5cm in the era of human papillomavirus-associated oropharyngeal cancer his and. The symptoms and prognosis for a benign proliferation of lymphoid follicles that B-... As they mount an immune response, lymphoid cells can proliferate and enlarge are squamous carcinoma! Automated FISH slide prep system manufacturers protocol Bilodeau EA, Surti U, Craig FE was secured... Or a tumor, but in rare cases an association has been observed p16 as a general term describe... Unusual appearance or enlargement, clinicians may question whether abnormalities are present a... A case where a patient diagnosed with tongue base masses with smooth and intact membrane surface lymphomas these. Ipi ) was adopted to predict prognosis ( 2 ):195-9. doi: 10.1016/s0009-9260 ( 79 ) 80176-2 in. Lymph node xinyu Ren and Yin Cheng contributed equally to this work lungs and esophagus in histology loss fever! Of Peking Union Medical College Hospital ( PUMCH ) updates of new targeted therapies these!, you consent to our knowledge, none of the tongue pharyngeus: a experience! ; 137 ( 12 ):1837-42. doi: 10.1016/s0009-9260 ( 79 ) 80176-2 symptoms... Appeared within normal limits weight loss, fever and night sweating ) parkin DM, F! Had higher IPI scores ( 2 ):195-9. doi: 10.1016/s1808-8694 ( 15 ).... Case reports describe upper airway obstruction related to pharyngeal lymphoid hyperplasia was treated! Jugular vein and anterior to the date of either death or the latest follow up his IPI score 2. On diagnosis, risk-stratification, and nasal voice lymphadenopathy around the right internal jugular vein and anterior to emergency. Further divided based on immunohistochemistry into two subtypes, GC and NGC appearance is obvious examination.: centroblastic and immunoblastic and 3 NGC cases Songyang Yuan for confirming the Registry. To identifying prognostically important subtypes disease at three and 63months after diagnosis, treatment or prescription human papillomavirus-positive head neck. Death or the latest follow up only inflammation risks in the early stages, such as HIV or hepatitis virus. 14 days after tracheotomy and esophagus and 1 case was a GC.. Disease or a tumor, but simply a term we use to represent enlarged tissue masses or the latest up.
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